Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID manustest7
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-06-19 23:49
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment sanja

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 30 individuals with a value less than 0.63 were subsequently diagnosed with PD. That is, 71.43% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.63 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 5, 'TN': 6, 'TP': 37, 'FP': 24}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 17, 'TN': 12, 'TP': 25, 'FP': 18}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 7, 'TN': 8, 'TP': 35, 'FP': 22}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 5, 'TN': 3, 'TP': 37, 'FP': 27}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 4.08
timePerCircleCoV 0.109074
timePerCircleSlope -0.0124777
meanError 1.67899
tremorFreq 6.64062
tremorRelPower 15.9718
tremorGyroAmpMean 0.00942157
tremorGyroAmpSlope -1.10789e-06
tremorGyroAmpCoV 0.289566
tremorCoordAmpMean 0.0334835
tremorCoordAmpSlope 0.000744616
tremorCoordAmpCoV 0.187834
tremorAccAmpMean 0.0151716
tremorAccAmpSlope 0.00776857
tremorAccAmpCoV 0.263223
tremorPcRelVar 0.576623
tremorPcX 0.410199
tremorPcY 0.911996

Circle Segment 1

Duration 5.0 s, Accuracy Estimate 2.092 (lower is better)

Circle Segment 2

Duration 4.16 s, Accuracy Estimate 1.769 (lower is better)

Circle Segment 3

Duration 4.04 s, Accuracy Estimate 1.467 (lower is better)

Circle Segment 4

Duration 3.8 s, Accuracy Estimate 1.637 (lower is better)

Circle Segment 5

Duration 3.36 s, Accuracy Estimate 2.033 (lower is better)

Circle Segment 6

Duration 3.92 s, Accuracy Estimate 1.494 (lower is better)

Circle Segment 7

Duration 4.48 s, Accuracy Estimate 1.386 (lower is better)

Circle Segment 8

Duration 4.2 s, Accuracy Estimate 1.335 (lower is better)

Circle Segment 9

Duration 4.12 s, Accuracy Estimate 1.839 (lower is better)

Circle Segment 10

Duration 3.72 s, Accuracy Estimate 1.739 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 8.836
timePerSpiralCoV 0.196578
timePerSpiralSlope -0.0628558
meanError 1.93232
tremorFreq 7.12891
tremorRelPower 14.5753
tremorGyroAmpMean 0.0131302
tremorGyroAmpSlope 0.0018593
tremorGyroAmpCoV 0.345316
tremorCoordAmpMean 0.0424522
tremorCoordAmpSlope 0.0050601
tremorCoordAmpCoV 0.166852
tremorAccAmpMean 0.0182518
tremorAccAmpSlope 0.00483986
tremorAccAmpCoV 0.262206
tremorPcRelVar 0.550183
tremorPcX 0.830846
tremorPcY -0.556503

Spiral Segment 1

Duration 11.64 s, Accuracy Estimate 1.502 (lower is better)

Spiral Segment 2

Duration 11.4 s, Accuracy Estimate 1.466 (lower is better)

Spiral Segment 3

Duration 9.32 s, Accuracy Estimate 1.827 (lower is better)

Spiral Segment 4

Duration 9.88 s, Accuracy Estimate 1.653 (lower is better)

Spiral Segment 5

Duration 9.0 s, Accuracy Estimate 1.739 (lower is better)

Spiral Segment 6

Duration 8.12 s, Accuracy Estimate 1.966 (lower is better)

Spiral Segment 7

Duration 7.8 s, Accuracy Estimate 2.419 (lower is better)

Spiral Segment 8

Duration 7.52 s, Accuracy Estimate 2.03 (lower is better)

Spiral Segment 9

Duration 7.04 s, Accuracy Estimate 2.495 (lower is better)

Spiral Segment 10

Duration 6.64 s, Accuracy Estimate 2.225 (lower is better)

Elel

eDurationMean 0.317
eDurationStd 0.0341903
eDurationStdnorm 0.107856
eDurationMedian 0.315
eDurationQuartdelta 0.035
eDurationQuartdeltanorm 0.111111
eDurationKurt 3.0261
eDurationTrenddiff -0.0275
eDurationTrendratio 0.917293
eWidthMean 4.45478
eWidthStd 1.15411
eWidthStdnorm 0.259072
eWidthMedian 4.1535
eWidthQuartdelta 1.4625
eWidthQuartdeltanorm 0.352113
eWidthKurt 6.32419
eWidthTrenddiff -0.2925
eWidthTrendratio 0.931507
eHeightMean 10.3925
eHeightStd 2.13298
eHeightStdnorm 0.205241
eHeightMedian 10.1205
eHeightQuartdelta 2.223
eHeightQuartdeltanorm 0.219653
eHeightKurt 3.51468
eHeightTrenddiff -0.6435
eHeightTrendratio 0.938547
eAspectMean 0.427633
eAspectStd 0.0508843
eAspectStdnorm 0.118991
eAspectMedian 0.433418
eAspectQuartdelta 0.0773343
eAspectQuartdeltanorm 0.178429
eAspectKurt 2.63344
eAspectTrenddiff -0.0156746
eAspectTrendratio 0.964574
eSlantMean -0.0423007
eSlantStd 0.109945
eSlantStdnorm -2.59912
eSlantMedian -0.0642447
eSlantQuartdelta 0.15231
eSlantQuartdeltanorm -2.37078
eSlantKurt 3.06389
eSlantTrenddiff 0.100154
eRtopMean 0.69909
eRtopStd 0.078754
eRtopStdnorm 0.112652
eRtopMedian 0.700163
eRtopQuartdelta 0.0940116
eRtopQuartdeltanorm 0.134271
eRtopKurt 3.144
eRtopTrenddiff 0.0643143
eRbotMean 0.813846
eRbotStd 0.211711
eRbotStdnorm 0.260137
eRbotMedian 0.842832
eRbotQuartdelta 0.291641
eRbotQuartdeltanorm 0.346025
eRbotKurt 2.75481
eRbotTrenddiff -0.182542
eRrightMean 0.875742
eRrightStd 0.0415298
eRrightStdnorm 0.0474224
eRrightMedian 0.877258
eRrightQuartdelta 0.0616084
eRrightQuartdeltanorm 0.0702284
eRrightKurt 2.93189
eRrightTrenddiff 0.0230332
eRleftMean 0.44785
eRleftStd 0.0795078
eRleftStdnorm 0.177532
eRleftMedian 0.460654
eRleftQuartdelta 0.0953454
eRleftQuartdeltanorm 0.206978
eRleftKurt 2.70274
eRleftTrenddiff -0.0429873
lDurationMean 0.473906
lDurationStd 0.0593613
lDurationStdnorm 0.12526
lDurationMedian 0.475
lDurationQuartdelta 0.1
lDurationQuartdeltanorm 0.210526
lDurationKurt 1.95933
lDurationTrenddiff -0.0925
lDurationTrendratio 0.824645
lWidthMean 6.55566
lWidthStd 1.29827
lWidthStdnorm 0.198038
lWidthMedian 6.552
lWidthQuartdelta 1.755
lWidthQuartdeltanorm 0.267857
lWidthKurt 3.99239
lWidthTrenddiff 0.819
lWidthTrendratio 1.13725
lHeightMean 26.5224
lHeightStd 3.31212
lHeightStdnorm 0.12488
lHeightMedian 25.7985
lHeightQuartdelta 4.1535
lHeightQuartdeltanorm 0.160998
lHeightKurt 2.58763
lHeightTrenddiff -2.1645
lHeightTrendratio 0.920086
lAspectMean 0.2485
lAspectStd 0.0457933
lAspectStdnorm 0.184279
lAspectMedian 0.233824
lAspectQuartdelta 0.0629062
lAspectQuartdeltanorm 0.269032
lAspectKurt 2.70945
lAspectTrenddiff 0.0560364
lAspectTrendratio 1.25679
lSlantMean 0.010221
lSlantStd 0.0690993
lSlantStdnorm 6.76051
lSlantMedian 0.0242644
lSlantQuartdelta 0.0852127
lSlantQuartdeltanorm 3.51184
lSlantKurt 3.00806
lSlantTrenddiff 0.0725834
lRtopMean 0.838377
lRtopStd 0.0594557
lRtopStdnorm 0.0709176
lRtopMedian 0.83631
lRtopQuartdelta 0.090295
lRtopQuartdeltanorm 0.107968
lRtopKurt 4.78328
lRtopTrenddiff 0.0743386
lRbotMean 0.837199
lRbotStd 0.258515
lRbotStdnorm 0.308785
lRbotMedian 0.782609
lRbotQuartdelta 0.313591
lRbotQuartdeltanorm 0.400699
lRbotKurt 3.54575
lRbotTrenddiff -0.233056
lRrightMean 0.932694
lRrightStd 0.0283273
lRrightStdnorm 0.0303715
lRrightMedian 0.935303
lRrightQuartdelta 0.045499
lRrightQuartdeltanorm 0.0486463
lRrightKurt 2.30976
lRrightTrenddiff 0.0283541
lRleftMean 0.295453
lRleftStd 0.0694827
lRleftStdnorm 0.235173
lRleftMedian 0.283216
lRleftQuartdelta 0.0755193
lRleftQuartdeltanorm 0.266649
lRleftKurt 3.767
lRleftTrenddiff -0.060975

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

FITTS Short Modified

meanTouchScore 0.940414
sumTouchScores 38.557
meanMovementTime 0.47375
numTouches 41
undershootPercentage 0
overshootPercentage 14.6341

fitts_short data not in signals file.

FITTS Long Modified

meanTouchScore 0.961116
sumTouchScores 25.9501
meanMovementTime 0.721154
numTouches 27
undershootPercentage 0
overshootPercentage 3.7037

ZigZag

numZigzags 5
timePerZigzagMean 11.528
timePerZigzagCoV 0.0931501
timePerZigzagSlope -0.0489244
meanError 2.70553
tremorFreq 6.54297
tremorRelPower 15.6265
tremorGyroAmpMean 0.0172889
tremorGyroAmpSlope 0.00365739
tremorGyroAmpCoV 0.314143
tremorCoordAmpMean 0.0572984
tremorCoordAmpSlope 0.00684911
tremorCoordAmpCoV 0.522318
tremorAccAmpMean 0.0293743
tremorAccAmpSlope 0.00222231
tremorAccAmpCoV 0.298811
tremorPcRelVar 0.790056
tremorPcX -0.0968101
tremorPcY -0.995303

ZigZag Segment 1

Duration 13.24 s, Accuracy Estimate 2.743 (lower is better)

ZigZag Segment 2

Duration 11.88 s, Accuracy Estimate 2.575 (lower is better)

ZigZag Segment 3

Duration 10.6 s, Accuracy Estimate 2.665 (lower is better)

ZigZag Segment 4

Duration 11.12 s, Accuracy Estimate 2.868 (lower is better)

ZigZag Segment 5

Duration 10.8 s, Accuracy Estimate 2.676 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 7.712
timePerZigzagCoV 0.145571
timePerZigzagSlope -0.0897303
zigzagHeightMean 59.2583
zigzagHeightCoV 0.040086
zigzagHeightSlope 0.0222544
meanError 0.0396551
tremorFreq 5.46875
tremorRelPower 16.1994
tremorGyroAmpMean 0.0367502
tremorGyroAmpSlope 0.016639
tremorGyroAmpCoV 0.23106
tremorCoordAmpMean 0.119659
tremorCoordAmpSlope 0.0354499
tremorCoordAmpCoV 0.690165
tremorAccAmpMean 0.0555914
tremorAccAmpSlope 0.015089
tremorAccAmpCoV 0.315003
tremorPcRelVar 0.829007
tremorPcX -0.189216
tremorPcY 0.981936

ZigZag Offset Segment 1

Duration 9.28 s, Accuracy Estimate 0.034 (lower is better)

ZigZag Offset Segment 2

Duration 8.4 s, Accuracy Estimate 0.034 (lower is better)

ZigZag Offset Segment 3

Duration 7.28 s, Accuracy Estimate 0.039 (lower is better)

ZigZag Offset Segment 4

Duration 7.16 s, Accuracy Estimate 0.033 (lower is better)

ZigZag Offset Segment 5

Duration 6.44 s, Accuracy Estimate 0.058 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.66}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.63}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.8599494520036479}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Healthy’, ‘BM_HC_Sep22_score’: 0.7963384891934702}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.7740070014563843}